Athletes
| # | Athlete | G · S · B | Total | ||
|---|---|---|---|---|---|
| 1 | Amantle Montsho Women · 2003–19 | 4 Jul 1983 | 200m, 400m, relays | 11 gold 4 silver 2 bronze | 17 |
| 2 | Oarabile Babolayi Women · 2011–19 | 8 Mar 1992 | 100m hurdles, 400m hurdles, relays | 6 gold 3 silver 2 bronze | 11 |
| 3 | Galefele Moroko Women · 2013–25 | 16 Apr 1997 | 400m, relays | 6 gold 1 silver 4 bronze | 11 |
| 4 | Loungo Matlhaku Women · 2010–18 | 24 Mar 1995 | 100m, 200m, relays | 3 gold 4 silver 5 bronze | 12 |
| 5 | Goitseone Seleka Women · 2011–17 | 10 Aug 1988 | 400m, relays | 2 gold 4 silver 2 bronze | 8 |
| 6 | Obakeng Kamberuka Women · 2024–26 | 8 Sep 2003 | 400m, relays | 2 gold 2 silver 2 bronze | 6 |
| 7 | Christine Botlogetswe Women · 2014–22 | 1 Oct 1995 | 400m, relays | 2 gold 1 silver 2 bronze | 5 |
| 8 | Motlatsi Rante Women · 2019–25 | 31 Oct 2000 | 800m, relays | 2 gold 0 silver 1 bronze | 3 |
| 9 | Amantle Sawe Mhutsiwa Women · 2025 | 5 Mar 2007 | 100m, relays | 2 gold 0 silver 0 bronze | 2 |
| 10 | Dithapelo Molepi Women · 1995–99 | 30 Nov 1975 | 400m, 800m | 1 gold 2 silver 3 bronze | 6 |
| 11 | Lydia Mashila Women · 2011–15 | 22 Jul 1990 | 400m, relays | 1 gold 2 silver 2 bronze | 5 |
| 12 | Oratile Nowe Women · 2019–26 | 20 May 2000 | 800m, relays | 1 gold 2 silver 1 bronze | 4 |
| 13 | Tsaone Sebele Women · 2019 | 27 Oct 1993 | 100m, 200m, relays | 1 gold 2 silver 0 bronze | 3 |
| 14 | Tlhomphang Basele Women · 2019–24 | 28 Feb 2000 | 400m, relays | 1 gold 1 silver 1 bronze | 3 |
| 15 | Golekanye Chikani Women · 2025 | 14 Mar 2002 | 400m, relays | 1 gold 1 silver 0 bronze | 2 |
| 16 | Tlhalefang Seleke Women · 2005–07 | – | Shot put | 1 gold 0 silver 1 bronze | 2 |
| 17 | Naledi Monthe Women · 2025 | 1 Aug 2003 | 400m, relays | 1 gold 0 silver 1 bronze | 2 |
| 18 | Goitseone Joel (2004) Women · 2023 | – | High jump | 1 gold 0 silver 0 bronze | 1 |
| 19 | Sethunya Majama Women · 2025 | – | relays | 1 gold 0 silver 0 bronze | 1 |
| 20 | Winnie Sarefo Women · 2025 | 22 Jul 2003 | relays | 1 gold 0 silver 0 bronze | 1 |
| 21 | Boitshepiso Kelapile Women · 2025 | 4 Mar 2002 | relays | 1 gold 0 silver 0 bronze | 1 |
| 22 | T. Moremi Women · 1988 | – | 1500m, 3000m | 0 gold 2 silver 0 bronze | 2 |
| 23 | Boikhutso Ramonene Women · 1997 | 1 Apr 1982 | 800m | 0 gold 1 silver 1 bronze | 2 |
| 24 | Refilwe Murangi (1999) Women · 2019 | – | 200m, relays | 0 gold 1 silver 1 bronze | 2 |
| 25 | Lydia Jele Women · 2024 | 22 Jun 1990 | relays | 0 gold 1 silver 1 bronze | 2 |
Only international medals count: national championship titles are left out.